Answer 5 Spironolactone. Gynecomastia in patients with chronic liver disease is caused by reduced catabolism of androstenedione. Many patients with liver cirrhosis take the diuretic spironolactone for cirrhotic ascites or for hypertension; spironolactone is a known inhibitor of testosterone synthesis and thus contributes to feminization in these patients. Click here to return to the questions

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